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氮吹仪厂家下可被肠液中的

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!细胞合成进入小肠时,在 [email protected] B存在氮吹仪厂家下可被肠液中的肠激酶激活,从 C端水解下一个 六肽,胰蛋白酶一级结构改变后,分子构象改变卷曲形成活性中心,于是无活性的胰蛋白酶原变成有活性 的胰蛋白酶(@DE个 %%,图 !F)。 ##胰蛋白酶原被激活后,生成的胰蛋白酶对胰蛋白酶原有自身激活作用,这大大加速了该酶的激活作 用,同时胰蛋白酶还可激活胰凝乳蛋白酶原,羧基肽酶原 %和弹性蛋白酶原等(表 !!),加速肠道对食 物的消化过程。血液中血液凝固与纤维蛋白溶解系统的激活也具有典型的逐步放大效应,呈级联反应。 少量凝血因子被激活时,可通过瀑布式放大作用,使大量凝血酶原转化为凝血酶,迅速引起血液凝固的发 生。 第五章 #酶"! 图 ! "#胰蛋白酶原的激活 ##酶原形式的存在及酶原的激活有重要生理意义。消化道蛋白酶以酶原形式分泌,避免了胰腺细胞和 细胞外间质的蛋白被蛋白酶水解而破坏,并保证酶在特定环境及部位发挥其催化作用。正常情况下血管 内凝血酶原不被激活,则无血液凝固发生,保证血流通畅运行。一旦血管破损,凝血酶原被激活成凝血酶, 血液凝固,催化纤维蛋白酶原变成纤维蛋白阻止大量失血,起保护机体作


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